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- Regenerative therapies (home & clinic)

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HRT, testosterone replacement therapy, supplementation and medication

Nuchido Time +™ is a supplement containing a scientific blend of vitamins, botanicals, and other supportive ingredients.

It is a powerful next generation NAD+ supplement to support your cellular health.

Our team of scientists have created a patented formulation that increases NAD+ levels by addressing the root causes of NAD+ decline. It is clinically proven in a double blinded placebo controlled crossover study.

- Vitamin C & zinc are antioxidants which contribute to the protection of cells from oxidative stress.

- Vitamin C & niacin contribute to normal energy-yielding metabolism & the reduction of tiredness and fatigue and normal psychological function.

- Zinc contributes to normal DNA and protein synthesis.

- Niacin & Vitamin C contributes to normal functioning of the nervous system.

- Zinc has a role in the process of cell division.

- Niacin contributes to the maintenance of normal mucous membranes.

- Niacin contributes to the maintenance of normal skin.

- Vitamin C contributes to normal collagen formation for the normal function of blood vessels, bones, cartilage, gums, skin.

- Vitamin C & zinc contribute to the normal function of the immune system.

- Zinc contributes to normal cognitive function.

- Zinc contributes to normal macronutrient metabolism.

- Zinc contributes to normal protein synthesis.

- Zinc contributes to the maintenance of normal bones, hair, nails & skin, vision.

- Parsley may help to support healthy kidney function.

- Green Tea may help to protect cells from oxidative stress, to maintain energy levels, support a healthy mind and cognitive function, and support normal immune function.

GlycanAge offers objective insight into the current state of low-grade chronic inflammation and is the only biological age test currently on the market to evaluate the effects of lifestyle interventions. 

GlycanAge is unique amongst ageing clocks. Unlike other clocks, it integrates genetic, epigenetic, and environmental aspects of ageing.

GlycanAge measures the composition of the IgG glycome (glycans attached to IgG). 

The IgG glycome not only changes with age but also affects inflammation at many levels. Glycans are not only biomarkers but also functional effectors of ageing. 

Many studies show accelerated glycan ageing is associated with both unhealthy lifestyles and diseases. In some cases, glycans were also shown to be causal for disease development.

Uniquely, GlycanAge responds to lifestyle interventions. Our studies demonstrate how lifestyle interventions, known to be beneficial for health and aging, measurably reverse glycan aging. This makes it an ideal measure for longevity treatment.

Based on the available evidence we conclude that the beneficial effects of mtfmn on aging and healthspan are primarily indirect via its effects on cellular metabolism and result from its anti-hyperglycemic action, enhancing insulin sensitivity, reduction of oxidative stress and protective effects on the endothelium and vascular function.

The numerous beneficial health outcomes associated with the use of mtfn to treat patients with type 2 diabetes (T2DM), together with data from pre-clinical studies in animals including the nematode, C. elegans, and mice have prompted investigations into whether mtfmn has therapeutic utility as an anti-aging drug that may also extend lifespan. Indeed, clinical trials, including the MILES (Mtfmn In Longevity Study) and TAME (Targeting Aging with Mtfmn), have been designed to assess the potential benefits of mtfmn as an anti-aging drug. 

Preliminary analysis of results from MILES indicate that mtfmn may induce anti-aging transcriptional changes; however it remains controversial as to whether mtfmn is protective in those subjects free of disease. Furthermore, despite clinical use for over 60 years as an anti-diabetic drug, the cellular mechanisms by which mtfmn exerts either its actions remain unclear. 

In this review, we have critically evaluated the literature that has investigated the effects of mtfmn on aging, healthspan and lifespan in humans as well as other species. In preparing this review, particular attention has been placed on the strength and reproducibility of data and quality of the study protocols with respect to the pharmacokinetic and pharmacodynamic properties of mtfmn. 

We conclude that despite data in support of anti-aging benefits, the evidence that mtfmn increases lifespan remains controversial. However, via its ability to reduce early mortality associated with various diseases, including diabetes, cardiovascular disease, cognitive decline and cancer, mtfmn can improve healthspan thereby extending the period of life spent in good health. Based on the available evidence we conclude that the beneficial effects of mtfmn on aging and healthspan are primarily indirect via its effects on cellular metabolism and result from its anti-hyperglycemic action, enhancing insulin sensitivity, reduction of oxidative stress and protective effects on the endothelium and vascular function.

Review Front Endocrinology 

2021 Aug 5:12:718942. 

doi: 10.3389/fendo.2021.718942.  eCollection 2021.

Ibrahim Mohammed  , Morley D Hollenberg , Hong Ding, Chris R Triggle 

PMID: 34421827  

"Outlive: A Physician's Framework for Maximum Lifespan" by Peter Attia explores the science behind extending lifespan and optimizing healthspan. Attia, a former surgeon and longevity enthusiast, delves into various factors that influence aging, including diet, exercise, sleep, stress management, and genetics. He emphasizes the importance of personalized approaches to health, advocating for understanding one's unique biological markers and tailoring lifestyle choices accordingly.The book outlines actionable strategies for improving longevity, such as adopting a low-carbohydrate, high-fat diet, incorporating regular exercise, prioritizing quality sleep, and managing stress through mindfulness practices. Attia also explores the role of fasting and the potential benefits of caloric restriction in promoting longevity and delaying age-related diseases.Drawing from his own experiences and extensive research, Attia provides insights into the mechanisms of aging, including inflammation, oxidative stress, and mitochondrial dysfunction. He discusses emerging technologies and interventions, such as genetic testing, personalized medicine, and senolytics, that hold promise for extending lifespan and improving health in the future.Overall, "Outlive" offers a comprehensive framework for individuals seeking to optimize their health and prolong their lifespan through evidence-based strategies and personalized approaches tailored to individual needs and genetic predispositions.

"Anti-Cancer: A New Way of Life" by David Servan-Schreiber explores the connection between lifestyle choices and cancer prevention and treatment. As a physician and cancer survivor himself, Servan-Schreiber combines scientific research with personal experience to offer a comprehensive guide to reducing cancer risk and enhancing resilience against the disease.The book delves into the environmental and lifestyle factors that contribute to cancer development, including diet, exercise, stress, environmental toxins, and social connections. Servan-Schreiber emphasizes the importance of adopting a holistic approach to health that encompasses both traditional medical treatments and lifestyle modifications.Servan-Schreiber discusses the role of nutrition in cancer prevention, highlighting the benefits of a diet rich in fruits, vegetables, whole grains, and omega-3 fatty acids while minimizing processed foods, sugar, and unhealthy fats. He also explores the potential anticancer properties of specific foods and nutrients, such as turmeric, green tea, and cruciferous vegetables.Furthermore, the book addresses the impact of stress on cancer progression and immune function, advocating for stress-reducing techniques such as mindfulness meditation, yoga, and social support. Servan-Schreiber also examines the potential benefits of physical activity in reducing cancer risk and improving outcomes for cancer survivors.Through practical advice and evidence-based recommendations, "Anti-Cancer: A New Way of Life" empowers readers to take proactive steps towards cancer prevention and support their body's natural defenses against the disease. It encourages a mindset shift towards embracing a healthier lifestyle and fostering resilience in the face of cancer.

"How Not to Die" by Michael Greger explores the link between diet and lifestyle choices and the prevention of chronic diseases, including heart disease, cancer, diabetes, and more. Greger, a physician and internationally recognized nutrition expert, distills extensive scientific research into practical advice for optimizing health and longevity.The book examines the leading causes of premature death and disability, emphasizing the role of diet in preventing and reversing chronic diseases. Greger advocates for a whole-food, plant-based diet rich in fruits, vegetables, legumes, nuts, and seeds, while minimizing processed foods, animal products, and added sugars.Greger provides evidence-based recommendations for specific foods and nutrients that have been shown to promote health and reduce disease risk, such as leafy greens, berries, flaxseeds, and turmeric. He also explores the benefits of adopting a primarily plant-based diet for weight management, blood pressure control, cholesterol reduction, and blood sugar regulation.Additionally, the book addresses lifestyle factors beyond diet that contribute to overall health and well-being, including exercise, sleep, stress management, and social connections. Greger emphasizes the importance of regular physical activity, sufficient sleep, and stress-reduction techniques in supporting optimal health and longevity.Through accessible language and compelling research, "How Not to Die" empowers readers to make informed choices about their diet and lifestyle, with the goal of preventing chronic diseases and maximizing longevity. Greger's evidence-based approach and practical tips make it a valuable resource for anyone interested in improving their health and reducing their risk of premature death.

Ageing is chronology-related and can be attributed to:

• Bone reabsorption
• Atrophy of facial muscles and reorganisation of adipose tissues
• Decrease in collagen and hyaluronic acid, laxity and ptosis of skin and subcutaneous tissues, pigmentation
• Environmental factors
• Gravity

• Bone: support and foundation
• Muscle: dynamic and static wrinkle
• Fat pads: volume and contours
• Skin: texture, tone and pigmentation

The midcheek manifests the most complex soft tissue changes with ageing. The development of the tear-trough deformity, malar mounds, and prominent nasolabial fold and groove may, to a significant degree, be attributed to the loss of projection of the maxilla with ageing.

The dentate mandible expands continuously with ageing. The mandibular angle increases; the ramus height and mandibular body height and length decreases. The jowl appears more prominent in relation to the area of reduced skeletal support in the prejowl area of the mandible.

Time has an effect on muscles; sarcopenia is the loss of lean body mass with ageing. Overall, it results in muscle weakness, lower muscle mass and impaired performance. With ageing, interleukin-6 becomes chronically elevated and promotes muscle catabolism most likely via suppressors of cytokine signalling proteins. While some muscles become looser with age, others actually tighten; such as the platysma bands, which stretch from the chin to the collarbone area, and become more pronounced with age.

Weakening of the malar and orbital ligaments is one of the more common events related to the ageing process. It is due to the sliding of the malar fat pad downwards and medially over the supporting ligaments of the nasolabial folds. This causes the cheeks to appear hollow. The orbital ligaments also become weaker and this contributes to the appearance of a depression below the orbits.

The adipose tissue of the face is organised evenly between the deep and superficial layers, divided by a superficial muscular-aponeurotic system (SMAS). The superficial portion is a continuous layer interfaced with fibrous septa connecting the SMAS to the dermis. The deep layer is divided into distinct anatomical compartments delimited by ligamentous structures. There are 3 compartments in the frontal region, 3 in the periorbital areas, and 5 superficial and 4 deep areas in the cheeks. The infraorbital fat, the medial cheek fat, and the nasolabial fat together constitute the malar fat pad. Some areas are subject to atrophy of the soft tissues (frontal, temporal, periorbital, perioral, jaw and chin) and others become hypertrophic (submandibular, nasolabial, labiomental, cheeks, infraorbital fat bags, and malar fat pads).

As skin ages, atrophic laxity (loss of collagen and firmness) leads to tissue descent (sag).

Characteristics of ageing skin include:

• Thickening of the keratin layer
• Uneven melanin pigmentation
• Flattening of the epidermis-dermis junction, decrease in collagen (thinning of the skin)
• Blood vessels become dilated and thinned with weakened walls, prone to rupture
• Dry (less sebum production)

Bone and cartilaginous structures become more visible as skin and subcutaneous tissue get thinner; the texture of the skin is altered and convexities turn into concavities (temporal, perioral and orbital areas).

Areas with a thin epidermis (eyes and lips) become wrinkled first. Hyaluronic acid (HA) is one of the most important components of maintaining skin hydration as part of the extracellular matrix. Every 10 years we lose 6% of endogenous HA.

Coloured skins present less severe intrinsic facial ageing. The signs would appear a decade later than in other skin types. They also tend to have a stronger bone structure: ageing more slowly as longer-lasting soft tissues support.

Asian and dark skin has thicker and more compact dermis than fair skin. It contributes to the lower incidence of expression wrinkles. Darker skin types are thought to have more cornified cell layers and greater lipid content compared to the white stratum corneum.

Darker skin has more, larger and more nucleated fibroblasts, smaller collagen fibre bundles and more macrophages than white skin.